Non-invasive method of physiologic vibration quant

专利名称：Non-invasive method of physiologic

vibration quantification

发明人：Kenneth J. McLeod,Robert Huang,Clinton T.

Rubin

申请号：US09498962申请日：20000204公开号：US06234975B1公开日：20010522

专利附图：

摘要：The present disclosure describes a method of determining the onset ofosteoporosis by measuring the vibrational response of the musculoskeletal system. Risk

of fracture of bones due to osteoporosis is mainly determined by three risk factors:muscle strength, bone mass, and postural stability. Because these three risk factors forfractures are interrelated and dependent on muscle function, they can be determined byquantifying physiologic vibration non-invasively using a low-mass accelerometer placed atan appropriate muscle belly. Muscle vibrations are produced by force fluctuations ofunfused motor units during contraction and are expressed by the lateral expansion ofmuscle fibers. Muscle vibrational characteristics span a broad (0-100 Hz) frequencyregime, directly reflecting the force provided by the muscle fibers being utilized and thenature of the dynamic mechanical milieu experienced by the skeleton during postural orlocomotory muscle activity. In addition vibrational information below 5 Hz has beenshown to correspond to postural instability. Also, a specific frequency component of themuscle vibration spectrum (25-50 Hz) has now been shown to represent the contributionof fast-oxidative fibers which are well correlated to the bone mineral density of humans.Thus, all three of the major risk factors of fracture are measured by a simplemeasurement of the musculoskeletal vibration spectrum using physiologic vibrationquantification.

申请人：RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

代理机构：Dilworth & Barrese

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