专利名称：Synthesis of histamine dihydrochloride发明人：WEN-LUNG YEH,CASIMIR ANTCZAK,JEFFRY
DAVID MCGOLRICK,MICHAEL JOSEPHROTH,MARK WRONA
申请号：AU2482500申请日：19991220公开号：AU763523B2公开日：20030724
摘要：The invention relates to the preparation of pharmaceutical grades of histaminedihydrochloride using a two step non-enzymatic synthetic method. The inventiondescribes the synthesis of histamine dihydrochloride by the non-enzymatic
decarboxylation of histidine and the step wise conversion of the decarboxylated productto the dihydrochloride salt form. The invention considers a final product of histaminedihydrochloride containing less than each of the following: 0.8% L-histidine HCI
monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to beacceptable for pharmaceutical use.
申请人：MAXIM PHARMACEUTICALS, INC.
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