专利名称：Animal model with disrupted FGF-9 gene发明人：David M. Ornitz,Jennifer S. Colvin申请号：US09/2566申请日：19990224公开号：US06136040A公开日：20001024
摘要：A unique animal model is disclosed which is useful for studying the role of FGF-9activity in cardiovascular diseases. To provide this animal model, the FGF-9 gene isdisrupted in mice, that is, null mutation in the mouse FGF-9 gene is engineered. Thisknockout mouse was produced by deleting the sequences immediately downstream ofthe initiation methionine in exon 1. Analysis of the FGF-9 null embryos demonstratesperinatal lethality with apparent pathology in lung and cardiac tissue.
申请人：WASHINGTON UNIVERSITY
代理人：Scott J. Meyer
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